Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
In our MS study, we are testing our hypothesis that cytotoxic autoreactive T-cells (Tcars) reverse MS disease by directly promoting endogenous brain repair mechanisms. In the short term, using an in vitro approach, this project will determine if Tcars can directly maintain oligodendrocyte health and function (myelination). In the long term, we will determine if the neuroreparative role of Tcars can be used in various models of demyelinating disease.
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Autoregulatory CD8 T cells depend on cognate antigen recognition and CD4/CD8 myelin determinants.
Ortega SB, Kashi VP, Cunnusamy K, Franco J, Karandikar NJ.Neurol Neuroimmunol Neuroinflamm. 2015 Nov 4;2(6):e170. doi: 10.1212/NXI.0000000000000170. eCollection 2015 Dec.PMID: 26587555
Ortega SB, Kashi VP, Tyler AF, Cunnusamy K, Mendoza JP, Karandikar NJ.J Immunol. 2013 Jul 1;191(1):117-26. doi: 10.4049/jimmunol.1300452. Epub 2013 Jun 3.PMID: 23733879
Clonal composition of neuroantigen-specific CD8+ and CD4+ T-cells in multiple sclerosis.
Biegler BW, Yan SX, Ortega SB, Tennakoon DK, Racke MK, Karandikar NJ.J Neuroimmunol. 2011 May;234(1-2):131-40. doi: 10.1016/j.jneuroim.2011.02.001. Epub 2011 Mar 11.PMID: 21397340
Baughman EJ, Mendoza JP, Ortega SB, Ayers CL, Greenberg BM, Frohman EM, Karandikar NJ.J Autoimmun. 2011 Mar;36(2):115-24. doi: 10.1016/j.jaut.2010.12.003. Epub 2011 Jan 22.PMID: 21257291
Immune regulatory CNS-reactive CD8+T cells in experimental autoimmune encephalomyelitis.
York NR, Mendoza JP, Ortega SB, Benagh A, Tyler AF, Firan M, Karandikar NJ.J Autoimmun. 2010 Aug;35(1):33-44. doi: 10.1016/j.jaut.2010.01.003. Epub 2010 Feb 20.PMID: 20172692
Crawford MP, Yan SX, Ortega SB, Mehta RS, Hewitt RE, Price DA, Stastny P, Douek DC, Koup RA, Racke MK, Karandikar NJ.Blood. 2004 Jun 1;103(11):4222-31. doi: 10.1182/blood-2003-11-4025. Epub 2004 Feb 19.PMID: 14976054