Hyperacute Immune Responses Associate with Immediate Neuropathology and Motor Dysfunction in Large Vessel Occlusions.

Farooqui M, Ortega-Gutierrez S, Hernandez K, Torres V, Dajles A, Zevallos C, Quispe-Orozco D, Mendez-Ruiz A, Manzel K, Ten Eyck P, Travel D, Karandikar NJ, Ortega SB. Ann Clin Transl Neurol. 2022 Dec 28. doi: 10.1002/acn3.51719. PMID: 36579400

Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage.

Roa JA, Sarkar D, Zanaty M, Ishii D, Lu Y, Karandikar NJ, Hasan DM, Ortega SB, Samaniego EA. Sci Rep. 2020 Jul 16;10(1):11809. doi: 10.1038/s41598-020-68861-y. PMID: 32678268

B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice.

Ortega SB, Torres VO, Latchney SE, Whoolery CW, Noorbhai IZ, Poinsatte K, Selvaraj UM, Benson MA, Meeuwissen AJM, Plautz EJ, Kong X, Ramirez DM, Ajay AD, Meeks JP, Goldberg MP, Monson NL, Eisch AJ, Stowe AM. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4983-4993. doi: 10.1073/pnas.1913292117. Epub 2020 Feb 12. PMID: 32051245

T and B cell subsets differentially correlate with amyloid deposition and neurocognitive function in patients with amnestic mild cognitive impairment after one year of physical activity.

Poinsatte K, Smith EE, Torres VO, Ortega SB, Huebinger RM, Cullum CM, Monson NL, Zhang R, Stowe AM.Exerc Immunol Rev. 2019;25:34-49. PMID: 30785868

A Pilot Study Identifying Brain-Targeting Adaptive Immunity in Pediatric Extracorporeal Membrane Oxygenation Patients With Acquired Brain Injury.

Ortega SB, Pandiyan P, Windsor J, Torres VO, Selvaraj UM, Lee A, Morriss M, Tian F, Raman L, Stowe AM.Crit Care Med. 2019 Mar;47(3):e206-e213. doi: 10.1097/CCM.0000000000003621. PMID: 30640221

Adaptive lymphocyte profiles correlate to brain Aβ burden in patients with mild cognitive impairment.

Stowe AM, Ireland SJ, Ortega SB, Chen D, Huebinger RM, Tarumi T, Harris TS, Cullum CM, Rosenberg R, Monson NL, Zhang R.J Neuroinflammation. 2017 Jul 27;14(1):149. doi: 10.1186/s12974-017-0910-x. PMID: 28750671

Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair.

Selvaraj UM, Poinsatte K, Torres V, Ortega SB, Stowe AM.Neurotherapeutics. 2016 Oct;13(4):729-747. doi: 10.1007/s13311-016-0460-4. PMID: 27492770

Preconditioning-induced CXCL12 upregulation minimizes leukocyte infiltration after stroke in ischemia-tolerant mice.

Selvaraj UM, Ortega SB, Hu R, Gilchrist R, Kong X, Partin A, Plautz EJ, Klein RS, Gidday JM, Stowe AM.J Cereb Blood Flow Metab. 2017 Mar;37(3):801-813. doi: 10.1177/0271678X16639327. Epub 2016 Jul 21. PMID: 27006446

Autoregulatory CD8 T cells depend on cognate antigen recognition and CD4/CD8 myelin determinants.

Ortega SB, Kashi VP, Cunnusamy K, Franco J, Karandikar NJ.Neurol Neuroimmunol Neuroinflamm. 2015 Nov 4;2(6):e170. doi: 10.1212/NXI.0000000000000170. eCollection 2015 Dec. PMID: 26587555

Multiparameter Flow Cytometric Assays to Quantify Effector and Regulatory T-Cell Function in Multiple Sclerosis.

Sinha S, Crawford MP, Ortega SB, Karandikar NJ.J Mult Scler (Foster City). 2015 Jan;2(1):1000130. doi: 10.4172/2376-0389.1000130. PMID: 26137595

Stroke induces a rapid adaptive autoimmune response to novel neuronal antigens.

Ortega SB, Noorbhai I, Poinsatte K, Kong X, Anderson A, Monson NL, Stowe AM.Discov Med. 2015 May;19(106):381-92. PMID: 26105701

Perinatal chronic hypoxia induces cortical inflammation, hypomyelination, and peripheral myelin-specific T cell autoreactivity.

Ortega SB, Kong X, Venkataraman R, Savedra AM, Kernie SG, Stowe AM, Raman L.J Leukoc Biol. 2016 Jan;99(1):21-9. doi: 10.1189/jlb.5HI0914-447R. Epub 2015 Jun 2. PMID: 26038434

Quantification of neurovascular protection following repetitive hypoxic preconditioning and transient middle cerebral artery occlusion in mice.

Poinsatte K, Selvaraj UM, Ortega SB, Plautz EJ, Kong X, Gidday JM, Stowe AM.J Vis Exp. 2015 May 4;(99):e52675. doi: 10.3791/52675. PMID: 25993394

Single dose of glycoengineered anti-CD19 antibody (MEDI551) disrupts experimental autoimmune encephalomyelitis by inhibiting pathogenic adaptive immune responses in the bone marrow and spinal cord while preserving peripheral regulatory mechanisms.

Chen D, Blazek M, Ireland S, Ortega S, Kong X, Meeuwissen A, Stowe A, Carter L, Wang Y, Herbst R, Monson NL.J Immunol. 2014 Nov 15;193(10):4823-32. doi: 10.4049/jimmunol.1401478. Epub 2014 Oct 3. PMID: 25281717

Neuroantigen-specific autoregulatory CD8+ T cells inhibit autoimmune demyelination through modulation of dendritic cell function.

Kashi VP, Ortega SB, Karandikar NJ.PLoS One. 2014 Aug 21;9(8):e105763. doi: 10.1371/journal.pone.0105763. eCollection 2014. PMID: 25144738

Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells.

Cunnusamy K, Baughman EJ, Franco J, Ortega SB, Sinha S, Chaudhary P, Greenberg BM, Frohman EM, Karandikar NJ.Clin Immunol. 2014 May-Jun;152(1-2):115-26. doi: 10.1016/j.clim.2014.03.005. Epub 2014 Mar 20. PMID: 24657764

Repetitive hypoxic preconditioning induces an immunosuppressed B cell phenotype during endogenous protection from stroke.

Monson NL, Ortega SB, Ireland SJ, Meeuwissen AJ, Chen D, Plautz EJ, Shubel E, Kong X, Li MK, Freriks LH, Stowe AM.J Neuroinflammation. 2014 Jan 31;11:22. doi: 10.1186/1742-2094-11-22. PMID: 24485041

The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis.

Ortega SB, Kashi VP, Tyler AF, Cunnusamy K, Mendoza JP, Karandikar NJ.J Immunol. 2013 Jul 1;191(1):117-26. doi: 10.4049/jimmunol.1300452. Epub 2013 Jun 3. PMID: 23733879

IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice.

Gutierrez T, Mayeux JM, Ortega SB, Karandikar NJ, Li QZ, Rakheja D, Zhou XJ, Satterthwaite AB.Eur J Immunol. 2013 Feb;43(2):382-93. doi: 10.1002/eji.201142095. Epub 2012 Dec 18. PMID: 23169140

Clonal composition of neuroantigen-specific CD8+ and CD4+ T-cells in multiple sclerosis.Biegler BW, Yan SX, Ortega SB, Tennakoon DK, Racke MK, Karandikar NJ.J Neuroimmunol. 2011 May;234(1-2):131-40. doi: 10.1016/j.jneuroim.2011.02.001. Epub 2011 Mar 11. PMID: 21397340

Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis.

Baughman EJ, Mendoza JP, Ortega SB, Ayers CL, Greenberg BM, Frohman EM, Karandikar NJ.J Autoimmun. 2011 Mar;36(2):115-24. doi: 10.1016/j.jaut.2010.12.003. Epub 2011 Jan 22. PMID: 21257291

Immune regulatory CNS-reactive CD8+T cells in experimental autoimmune encephalomyelitis.York NR, Mendoza JP, Ortega SB, Benagh A, Tyler AF, Firan M, Karandikar NJ.J Autoimmun. 2010 Aug;35(1):33-44. doi: 10.1016/j.jaut.2010.01.003. Epub 2010 Feb 20. PMID: 20172692

In vitro methotrexate as a practical approach to selective allodepletion.

Sathe A, Ortega SB, Mundy DI, Collins RH, Karandikar NJ.Biol Blood Marrow Transplant. 2007 Jun;13(6):644-54. doi: 10.1016/j.bbmt.2007.01.081. Epub 2007 Mar 23. PMID: 17531774

Transient regulatory T-cells: a state attained by all activated human T-cells.

Pillai V, Ortega SB, Wang CK, Karandikar NJ.Clin Immunol. 2007 Apr;123(1):18-29. doi: 10.1016/j.clim.2006.10.014. Epub 2006 Dec 19. PMID: 17185041

Glatiramer acetate (GA) therapy induces a focused, oligoclonal CD8+ T-cell repertoire in multiple sclerosis.

Biegler BW, Yan SX, Ortega SB, Tennakoon DK, Racke MK, Karandikar NJ.J Neuroimmunol. 2006 Nov;180(1-2):159-71. doi: 10.1016/j.jneuroim.2006.07.015. Epub 2006 Aug 28. PMID: 16935352

Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis.

Tennakoon DK, Mehta RS, Ortega SB, Bhoj V, Racke MK, Karandikar NJ.J Immunol. 2006 Jun 1;176(11):7119-29. doi: 10.4049/jimmunol.176.11.7119. PMID: 16709875

High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay.

Crawford MP, Yan SX, Ortega SB, Mehta RS, Hewitt RE, Price DA, Stastny P, Douek DC, Koup RA, Racke MK, Karandikar NJ.Blood. 2004 Jun 1;103(11):4222-31. doi: 10.1182/blood-2003-11-4025. Epub 2004 Feb 19. PMID: 14976054